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本文采用国产原料试制氧氟沙星薄膜包衣片,并与日本第一制药株式会社生产的片剂进行了体外溶出度、体内相对生物利用度比较。体内血清药物浓度采用HPLC法测定。自制片剂与进口片剂生物等效。
In this paper, domestic raw materials trial of ofloxacin film-coated tablets, and Japan’s First Pharmaceutical Co., Ltd. tablets in vitro dissolution, the relative bioavailability in vivo comparison. In vivo serum drug concentration was determined by HPLC method. Homemade tablets are bioequivalent to imported tablets.