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作者用苯并咪唑类化合物:甲苯咪唑,苯硫咪唑,丙氧咪唑,硫氧咪唑,丙硫咪唑,氟苯咪唑和分子在5～8μm的微粒型硝硫氰胺,通过口服和皮下注射两种给药途径,对纳塔尔多乳鼠体内棉鼠丝虫和彭亨丝虫的杀虫效果作了比较。各种化合物的口服剂量为每月150mg/kg,连服5天。皮下注射为每日100mg/kg,连用5天。治疗前对所有感染动物作末梢血微丝蚴计数,治后分别于第1、8、23和43天作末梢血微丝蚴计数,并与治前计数相比以求得的百分率来衡量药物杀灭微丝蚴的效果;在治后43天剖检所有实验动物,观察虫体存活情况来评价杀灭成虫效果。
The authors used benzimidazole compounds: mebendazole, phenylthiazole, propionimidazole, thiamidazole, albendazole, flubendazole and molecules in the 5 ~ 8μm particulate nitrocytnamine by oral and subcutaneous injection of two The route of administration was compared with the insecticidal effect of cotton rat and penicillium wilt in Natal polygamous mice. Oral doses of various compounds are 150 mg / kg per month, even for 5 days. Subcutaneous injection of 100mg / kg daily, once every 5 days. Before treatment, all infected animals were counted for their peripheral blood microfilariae. After treatment, peripheral blood microfilariae were counted on days 1, 8, 23 and 43, respectively, and compared to the pre-treatment count, the drug was measured as a percentage Kill the effect of microfilariae; autopsy all the experimental animals 43 days after treatment to observe the survival of parasites to evaluate the effect of killing adults.