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目的:探讨非小细胞肺癌患者放疗前后血清CEA、CYFAR21-1、CA125的水平变化及其与放疗近期疗效的关系。方法:应用电化学发光法检测110例非小细胞肺癌放疗前后血清标志物CEA、CYFRA21-1及CA125的水平,同时评估放疗的近期疗效并分析肿瘤标志物的变化及与近期疗效的关系。结果:110例患者放疗后近期有效62例,无效48例,有效率56.36%;放疗后CA125、CYFRA21-1及CEA水平显著降低的患者,近期有效的阳性率分别为61.29%(38/62)、54.84%(34/62)和43.55%(27/62),联合3项检测对近期有效的阳性率为82.26%(51/62),高于单项检测(P均<0.05)。结论:血清肿瘤标志物CEA、CYFAR21-1、CA125水平检测可用于非小细胞肺癌患者放疗的近期疗效评估,联合3项指标检测的阳性率优于单项检测。
Objective: To investigate the changes of serum CEA, CYFAR21-1 and CA125 levels in patients with non-small cell lung cancer before and after radiotherapy and their relationship with the short-term efficacy of radiotherapy. Methods: The levels of CEA, CYFRA21-1 and CA125 in 110 non-small cell lung cancer patients before and after radiotherapy were detected by electrochemiluminescence. The curative effect of radiotherapy and the changes of tumor markers were analyzed. Results: Among the 110 patients, 62 cases were effective in the short term, 48 cases were ineffective, and the effective rate was 56.36%. The effective rates of the patients with significantly decreased level of CA125, CYFRA21-1 and CEA after radiotherapy were 61.29% (38/62) , 54.84% (34/62) and 43.55% (27/62), respectively. The positive rates of the three combined tests were 82.26% (51/62), higher than the single test (all P <0.05). Conclusion: The serum tumor markers CEA, CYFAR21-1 and CA125 levels can be used to evaluate the curative effect of radiotherapy in patients with non-small cell lung cancer. The positive rate of combined detection of three indexes is better than that of single detection.