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Background: Ultraviolet B (UVB) radiation can be used in the prevention and treatment of vitamin D deficiency. Aim: To investigate, in a controlled study of patients with cystic fibrosis (CF), whether regular UVB radiation would improve serum levels of calcidiol during the dark season (October-April). Methods: Thirty patients with mild to moderate disease were included (aged 9-40 y). All patients had cholecalciferol supplementation. One group (15 patients) was given UVB oneto three times a week for 6 mo and one group (15 sex-and age-matched patients) served as controls. The radiation source consisted of three TL 12/40W UVB fluorescent lamps. Initial treatment duration was 1 min, subsequently increased by 0.5-1 min/treatment to a maximum of 10 min. Results: The mean initial serum calcidiol levels were 21 ng/ml in the controls and 22 ng/ml in the intervention group. Serum calcidiol levels increased to 44 ng/ml after 8 wk and to 50 ng/ml after 24 wk of UVB radiation; the corresponding serum levels in the controls were 19 and 25 ng/ml, respectively. The mean serum calcitriol levels increased in the treated group and were unaltered in the control group. Conclusions: UVB radiation was effective in increasing vitamin D levels in patients with CF. The study resultsimply that UVB radiation is valuable in chronic conditions associated with vitamin D deficiency.
Background: Ultraviolet B (UVB) radiation can be used in the prevention and treatment of vitamin D deficiency. Aim: To investigate, in a controlled study of patients with cystic fibrosis (CF), whether regular UVB radiation would improve serum levels of calcidiol during All groups had cholecalciferol supplementation. One group (15 patients) was given UVB oneto three times a week for 6 (October-April). Methods: Thirty patients with mild to moderate disease were included (aged 9-40 y) The radiation source consisted of three TL 12 / 40W UVB fluorescent lamps. Initial treatment duration was 1 min, followed increased increased by 0.5-1 min / treatment to a maximum of 10 min. Results: The mean initial serum calcidiol levels were 21 ng / ml in the controls and 22 ng / ml in the intervention group. Serum calcidiol levels increased to 44 ng / ml after 8 wk and to 50 ng / ml after 24 wk of UVB radiation; the corresponding ser um levels in the controls were 19 and 25 ng / ml, respectively. The mean serum calcitriol levels increased in the treated group and were unaltered in the control group. Conclusions: UVB radiation was effective in increasing vitamin D levels in patients with CF. The study resultsimply that UVB radiation is valuable in chronic conditions associated with vitamin D deficiency.