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目的 :观察临床分离金葡菌对 6种氟喹诺酮类药物的耐药情况。方法 :用琼脂稀释法测定诺氟沙星 (NFLX)、氧氟沙星 (OFLX)、氟罗沙星 (FLRX)、环丙沙星 (CPFX)、司帕沙星 (SPFX)、托舒沙星 (TFLX) 6种 2、3代氟喹诺酮类药物对成都地区15 5株临床分离金葡菌的体外抗菌活性。结果 :金葡菌对 6种药物的耐药率分别为诺氟沙星 3 5 .5 % ,氟罗沙星 3 4 .19% ,环丙沙星 2 7.75 % ,托舒沙星 2 7.75 % ,氧氟沙星 2 5 .81% ,司帕沙星 2 5 .81%。结论 :氟喹诺酮类药物的广泛应用已使细菌的耐药性明显增高 ,各药MIC90 均超过 16mg·L-1,比以往文献报道的本地区金葡菌耐药性明显升高 ,提示要合理应用氟喹诺酮类药物 ,减少耐药菌株的增加。
Objective: To observe the clinical isolates of S. aureus on the six kinds of fluoroquinolones resistance. METHODS: NFLX, OFLX, FLRX, CPFX, sparfloxacin and tosufloxacin were measured by agar dilution method. In Vitro Antibacterial Activity of Six Kinds of 2,3 and Fluoroquinolones on 15 5 Staphylococcus aureus Isolated in. Results: The drug resistance rate of Staphylococcus aureus to 6 drugs were 35.5% of norfloxacin, 34.19% of fleroxacin, 7.75% of ciprofloxacin 2, 7.75% of tosufloxacin 2, Ofloxacin 25.81%, sparfloxacin 25.81%. Conclusion: The wide application of fluoroquinolones has made the bacterial resistance significantly increased, the MIC90 of each drug more than 16mg · L-1, compared with the previous reports of S. aureus resistance in the region was significantly increased, suggesting that reasonable Fluoroquinolones should be used to reduce the increase of drug-resistant strains.