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洁尔灭(氯苄烷铵)作为抗微生物防腐剂广泛用于药物制剂和卫生用品中,其主要成份为氯化C_(12)、C_(14)和C_(16)烷基二甲基苄铵。本文利用Hofmann降解反应将氯苄烷铵成份转化为易挥发的烷基二甲胺,再进行GC测定,降解反应迅速,条件温和,又可同质谱联用,因此较HPLC更适用于实验室常规分析。降解反应步骤先将样品用苯-DMSO(8∶2)配成1mg/ml的溶液,取该溶液2～10ml移至25ml磨口耐热玻璃试管中,加溶剂(同上)至刻度,再加入100mg特丁醇钾,用力振摇,室温放置10分钟后将反应液
Benzalkonium chloride (benzalkonium chloride) is widely used as an anti-microbial preservative in pharmaceutical preparations and sanitary products. Its main components are C 12, C 14 and C 16 alkyldimethylbenzyl chloride Ammonium. In this paper, the use of Hofmann degradation reaction of benzalkonium chloride component into volatile alkyldimethylamine, and then measured by GC, the degradation reaction is rapid, mild conditions, but also with the mass spectrometry, and therefore more suitable for HPLC than the laboratory routine analysis. Degradation reaction step first benzene-DMSO (8: 2) dubbed 1mg / ml solution, take the solution 2 ~ 10ml moved to 25ml mill heat-resistant glass tube, add solvent (above) to the mark, then add 100mg potassium tert-butoxide, shaking vigorously, after 10 minutes at room temperature the reaction solution