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在9名肝炎死亡病例尸检时,采集了多种组织,以斑点分子杂交技术及Southern吸印法检测了HBV-DNA,以免疫组织化学技术检测了各种组织细胞内的HBsAg、HBcAg和HBeAg。检测结果显示除肝脏外,HBV-DNA和/或HBV抗原常见于一些重要的肝外脏器和组织,说明了HBV的泛嗜性,并且提示可能与有些病症有关。睾丸和前列腺中检测到HBV抗原和HBV—DNA值得重视,为通过性生活可以传播及通过父亲也可以垂直传播给新生儿提供了依据。HBeAg在肝外组织中的检测尚未见报道,本组资料显示在多种肝外组织细胞内都可检出,说明在肝外组织中,HBV的复制也可以是活跃的。HBeAg大多存在于细胞核内,其意义尚待进一步探讨。
At the autopsy of 9 dead cases of hepatitis, a variety of tissues were collected. HBV-DNA was detected by dot blot hybridization and Southern blotting, and HBsAg, HBcAg, and HBeAg in various tissues were detected by immunohistochemistry. The test results showed that in addition to the liver, HBV-DNA and/or HBV antigens are common in some extrahepatic organs and tissues, indicating the ubiquitous nature of HBV and suggesting that it may be related to some conditions. The detection of HBV antigens and HBV-DNA in testis and prostate is worthy of attention, which can provide a basis for transmission through sexual life and vertical transmission to newborns through fathers. The detection of HBeAg in extrahepatic tissues has not been reported. The data in this group can be detected in a variety of extrahepatic tissues, indicating that in extrahepatic tissues, HBV replication can also be active. HBeAg mostly exists in the nucleus, and its significance remains to be further explored.