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一般认为非胰岛素依赖型糖尿病(NIDDM)无酮症倾向,但其血酮体仍有上升趋势,血酮体可视为代谢异常的指标。本文研究应用磺脲类降糖药控制血糖不佳的 NIDDM 患者其血酮体值,以探讨其是否可视为改用胰岛素治疗的指标。以经饮食或磺脲类药物治疗,而血红蛋白 A_1(HbA_1)值>10%,且持续3个月以上的 NIDDM 为观察对象,共60例。给加大磺脲类药物(优降糖剂量达7.5～10.0mg)而血糖控制满意者为非胰岛素需要(NIR)组;血糖控制仍不佳需改用胰岛素者为胰岛素
It is generally believed that non-insulin-dependent diabetes mellitus (NIDDM) has no ketosis tendency, but its blood ketone body is still on the rise. Blood ketone body can be regarded as an indicator of metabolic abnormality. This article studies the application of sulfonylurea hypoglycemic agents to control blood glucose levels in patients with poor blood glucose in patients with NIDDM to explore whether it can be considered as an indicator of switching to insulin therapy. In diet or sulfonylurea treatment, and hemoglobin A_1 (HbA_1) value> 10%, and for 3 months or more NIDDM were observed, a total of 60 cases. To increase the sulfonylureas (optimal hypoglycemic dose of 7.5 ~ 10.0mg) and those who are satisfied with the control of blood glucose for non-insulin needs (NIR) group; blood glucose control is still poor need to switch to insulin insulin