苯乙腈及其取代物是合成拟除虫菊酯类农药过程中的重要中间体。有关拟除虫菊酯农药已有较详尽的毒理学资料,但对其中间体的毒性研究尚未见报道,环境水平和环境行为特征也不清楚。王连生等曾对该类有机污染物在鱼体肌肉中的累积和释放行为及脂水分配系数进行过详细研究,提出了环境影响预测模型。本文选用11种苯乙腈取代物,测试了其对体外培养大鼠肝细胞的毒性,并建立毒性预测模型。 Phenylacetonitrile and its substitutes are important intermediates in the synthesis of pyrethroid pesticides. The pyrethroid pesticides have been more detailed toxicology information, but the toxicity of their intermediates has not been reported, the environmental level and environmental behavior characteristics are not clear. Wang Lian-sheng et al. Have conducted a detailed study on the accumulation and release behavior of such organic pollutants in the muscle of the fish and the lipid-water partition coefficient, and proposed the environmental impact prediction model. In this paper, 11 kinds of phenylacetonitrile substitutes were selected and their toxicity on rat hepatocytes cultured in vitro was tested. A toxicity prediction model was established.