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目的:通过检测心脏X综合征(CSX)患者血清半乳糖凝集素3(Galectin-3)水平,探讨其与CSX发病的相关性及临床意义。方法:纳入115例CSX患者(CSX组)和74名健康对照者(对照组),测定血清Galectin-3和高敏C反应蛋白(hs-CRP)及一些生化指标的浓度。结果:CSX患者血清Galectin-3浓度较对照组高(CSX组:0.90ng/ml,IQR:0.40~1.70ng/ml;对照组:0.40ng/ml,IQR:0.36~0.44ng/ml;P<0.0 001)。单因素Logistic分析显示,LnGalectin-3、Ln空腹葡萄糖、Lnhs-CRP、Ln尿酸的血清浓度与冠心病家族史都与CSX相关。多因素Logistic回归分析显示,LnGalectin-3、冠心病家族史、空腹血糖、Lnhs-CRP和Ln血尿酸是CSX的独立预测因子。糖尿病、高血压与CSX无明显相关性。Pearson相关分析表明血清LnGalectin-3与Ln hs-CRP显著正相关(r=0.16,P=0.03)。结论:CSX患者中血清Galectin-3浓度明显升高,Galectin-3表达与hs-CRP相关。
Objective: To investigate the correlation between galectin-3 and the pathogenesis of CSX by detecting the level of serum galectin-3 in patients with cardiac X syndrome (CSX). Methods: One hundred and fifteen CSX patients (CSX group) and 74 healthy controls (control group) were enrolled in this study. Serum levels of Galectin-3, hs-CRP and some biochemical parameters were determined. Results: The serum concentration of Galectin-3 in CSX patients was higher than that in the control group (CSX group: 0.90ng / ml, IQR: 0.40-1.70ng / ml; control group: 0.40ng / ml, IQR: 0.36-0.44ng / 0.0 001). Univariate Logistic analysis showed that serum concentrations of LnGalectin-3, Ln fasting glucose, Lnhs-CRP, and Ln uric acid were all associated with CSX family history. Multivariate Logistic regression analysis showed that LnGalectin-3, family history of coronary heart disease, fasting blood glucose, Lnhs-CRP and Ln uric acid were independent predictors of CSX. Diabetes, hypertension and CSX no significant correlation. Pearson correlation analysis showed that serum LnGalectin-3 was significantly and positively correlated with Ln hs-CRP (r = 0.16, P = 0.03). CONCLUSIONS: Serum Galectin-3 levels are significantly elevated in patients with CSX, and the expression of Galectin-3 is associated with hs-CRP.