目的：得到拟类脂Ａ的六肽。方法：用抗类脂Ａ的单克隆抗体筛选噬菌体随机六肽库，经四轮筛选后进行ＥＬＩＳＡ检测，用得到的１５个阳性克隆分别免疫小鼠，并将使小鼠产生抗ＬＰＳ抗体的１０个克隆进行测序，将保守序列进行肽合成。结果：得到保守序列为ＬｙｓＰｈｅＳｅｒＳｅｒＡｒｇ，即ＫＦＳＳＲＸ。固相合成此小肽可与其１Ｂ６抗体结合，且此结合可被ＬＰＳ抑制。结论：此六肽可模拟脂多糖或类脂Ａ表位 OBJECTIVE: To obtain the hexapeptide of lipid A. Methods: The phage random hexapeptide library was screened by anti-lipid A monoclonal antibody. After four rounds of screening, ELISA was performed. The 15 positive clones obtained were used to immunize mice and the mice were given anti-LPS antibody 10 The clones were sequenced and the conserved sequences were peptide synthesized. Results: The conservative sequence Lys Phe Ser Ser Arg, that is, KFSSRX. This small peptide can be bound to its 1B6 antibody by solid-phase synthesis and this binding can be inhibited by LPS. Conclusion: This hexapeptide mimics lipopolysaccharide or lipid A epitopes