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目的观察酪酸梭菌保留灌肠预防宫颈癌急性放射性直肠炎的临床疗效。方法将60例宫颈癌患者随机分为联合组(30例)和单纯放疗组(30例)。两组均给予根治性放射治疗(体外照射+腔内治疗),联合组在放疗期间给予每周三次酪酸梭菌保留灌肠,睡前执行,单放组治疗期间仅给予常规放疗。结果联合组I度放射性直肠炎发生率为5/30,Ⅱ度放射性直肠炎的发生率为2/30,无Ⅲ度放射性直肠炎的发生,单放组I度放射性直肠炎的发生率为16/30,Ⅱ度放射性直肠炎的发生率为8/30,Ⅲ度放射性直肠炎的发生率为2/30,两组比较差异有统计学意义(P<0.0001)。结论酪酸梭菌保留灌肠是预防急性放射性直肠炎的有效方法。
Objective To observe the clinical efficacy of Clostridium butyricum retention enema in the prevention of acute radiation proctitis of cervical cancer. Methods Sixty patients with cervical cancer were randomly divided into combined group (30 cases) and radiotherapy group (30 cases). Both groups were given radical radiotherapy (external beam irradiation + endovascular treatment). The combination group was given C. butyricum retention enema three times a week during radiotherapy and was performed before going to bed. The radiotherapy alone group was given only conventional radiotherapy. Results The incidence of I degree radiation proctitis was 5/30 in the combined group, the incidence of Ⅱ degree radiation proctitis was 2/30, and the incidence of Ⅲ degree radiographic proctitis was not found. The incidence of I degree radiotherapy was 16 / 30, the incidence of Ⅱ degree radiological proctitis was 8/30, the incidence of Ⅲ degree radiological proctitis was 2/30, the difference between the two groups was statistically significant (P <0.0001). Conclusion Clostridium butyricum retention enema is an effective method to prevent acute radiation proctitis.