Staurosporine是一种能降低人膀胱癌细胞的浸润,并从而抑制其穿透人工基底膜能力的细菌产物。研究结果提示,Staurosporine或更特异的类似物有可能最终用于预防转移癌的发生和发展。 Staurosporine能抑制蛋白激酶C(一种能影响数种癌细胞系的瘤细胞的细胞功能调节剂)。Schwartz等发现,Staurosporine在体外无毒浓度下可显著降低人膀胱癌EJ细胞系细 Staurosporine is a bacterial product that reduces the infiltration of human bladder cancer cells and thereby inhibits their ability to penetrate the artificial basement membrane. The results suggest that Staurosporine or more specific analogues may eventually be used to prevent the occurrence and progression of metastatic cancer. Staurosporine inhibits protein kinase C, a cell function regulator that affects several tumor cell lines. Schwartz et al. found that Staurosporine can significantly reduce the human bladder cancer EJ cell line at a non-toxic concentration in vitro.