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目的:观察疏血通注射液对急性脑梗死患者血清神经元特异性烯醇化酶(NSE)水平、神经功能缺损、日常生活活动能力的影响及临床疗效。方法:80例急性脑梗死患者随机分为疏血通治疗组(40例)与常规对照组(40例),均进行常规治疗,治疗组加用疏血通注射液,观察2组患者治疗前后的血清NSE水平、美国国立卫生研究院卒中量表(NIHSS)评分以及临床疗效。1个月后评价患者的Barthel指数(BI)。结果:2组患者治疗后血清NSE水平,NIHSS评分均较治疗前明显降低,并且疏血通治疗组较对照组下降更显著,差异有统计学意义(P<0.05);疏血通治疗组的治疗总有效率为87.5%,常规对照组为65%,差异有统计学意义(P<0.05);1个月时2组的BI指数与治疗前相比改善,而疏血通治疗组改善优于对照组,差异有统计学意义(P<0.05)。结论:疏血通注射液具有显著的神经元保护作用,能降低急性脑梗死后的血清NSE水平,促进神经功能恢复,减少致残率,改善患者的生活质量和预后。
Objective: To observe the effect of Shuxuetong injection on the levels of serum neuron-specific enolase (NSE), neurological impairment and activities of daily living in patients with acute cerebral infarction and its clinical efficacy. Methods: Eighty patients with acute cerebral infarction were randomly divided into Shuxuetong treatment group (40 cases) and routine control group (40 cases). All patients were treated routinely. Shuxuetong injection was used in the treatment group, Serum NSE levels, the National Institutes of Health Stroke Scale (NIHSS) score, and clinical efficacy. Patient’s Barthel Index (BI) was evaluated after 1 month. Results: After treatment, serum NSE level and NIHSS score of the two groups were significantly lower than those before treatment, and Shuxuetong treatment group decreased more significantly than the control group, the difference was statistically significant (P <0.05); Shuxuetong treatment group The total effective rate was 87.5% in the control group and 65% in the conventional control group, with significant difference (P <0.05). At 1 month, the BI index of the two groups improved compared with that before treatment, while the Shuxuetong treatment group improved In the control group, the difference was statistically significant (P <0.05). Conclusion: Shuxuetong injection has a significant neuronal protective effect, can reduce serum levels of NSE after acute cerebral infarction, promote neurological recovery, reduce the disability rate, improve patients’ quality of life and prognosis.