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目的通过没食子灌肠剂的急性毒性试验为临床安全用药提供参考。方法将KJA以最高剂量(1g.mL-1)小鼠单次灌肠给药,观察给药后的毒性反应并测定半数致死量、最大耐受量及相关指标。结果除了肝、肾、肠道切片结果中,给药组及对照组间出现差异外,其他相关指标均无出现组间差异(P>0.05)并各组小鼠没有发生死亡。结论没食子灌肠剂没有明显的急性毒性。
Objective To provide a reference for clinical safety medication by the acute toxicity test of Gallic enema. Methods KJA was given to the mice in the highest dose (1g.mL-1) once a single enema. Toxicity after administration was observed and the lethal dose, maximum tolerated dose and related indexes were determined. Results There were no significant differences among the other indexes except the results of liver, kidney and intestine slices between the administration group and the control group (P> 0.05), and no death occurred in the mice in each group. Conclusion There is no obvious acute toxicity of EGCG.