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雄性ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠，用乌拉坦（１２ｇ／ｋｇ）腹腔麻醉。在侧脑室注射（ｉｃｖ）神经降压素（ＮＴ）（１０，２０μｇ）可引起血压升高或降低，心率减慢。预先ｉｃｖα１受体阻断剂哌唑嗪（１５μｇ／３μｌ），可阻断ＮＴ的中枢升压反应；预先ｉｃｖＭ受体阻断剂硫酸阿托品（２５μｇ／３μｌ），可阻断ＮＴ的中枢降压反应；预先ｉｃｖＨ１受体阻断剂扑尔敏（５０μｇ／３μｌ）或Ｈ２受体阻断剂甲氰咪胍（２５０μｇ／３μｌ），对ＮＴ的中枢心血管效应均无明显影响。实验结果表明：脑中ＮＴ升高可使血压升高或降低；在ＮＴ引起升压反应的中枢环节中，有肾上腺素能α１受体活动的参与；在ＮＴ引起降压反应的中枢环节中，有胆碱能Ｍ受体活动的参与。可以设想，ＮＴ与儿茶酚胺及乙酰胆碱三者一起参与中枢对血压的调节。
Male Sprague-Dawley rats were anesthetized with urethane (1.2 g / kg) intraperitoneally. Intracerebroventricular injection (icv) of neurotensin (NT) (10, 20 μg) can cause an increase or decrease in blood pressure and a decrease in heart rate. Pre-icvα1 receptor blocker prazosin (1 5μg / 3μl), can block the central NT pressure response; pre-icvM receptor antagonist atropine sulfate (2μg / 3μl), can block NT Central antihypertensive response; no significant effect on the central cardiovascular effects of NT was observed with either icvH1 receptor blocker chlorpheniramine (50 μg / 3 μl) or the H2 receptor blocker cimetidine (250 μg / 3 μl). The experimental results show that the elevation of NT in the brain can increase or decrease the blood pressure. In the central part of NT-induced vasorelaxation, there is the participation of adrenergic α1-receptor activity. In the central part of NT-induced hypotensive response, Cholinergic M receptor activity involved. Can imagine, NT and catecholamines and acetylcholine together with the three involved in the regulation of blood pressure.