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我们试用绿茶胶囊Ⅰ、Ⅱ、Ⅲ、Ⅳ干预食管上皮重度增生(简称重增)患者,初步获得逆转重增和阻断癌变的作用。 1986年10月,经食管脱落细胞学检查确诊患者100例,随机双盲分2组设计。干预组64例,男33例,女31例;平均年龄54岁。安慰组36例,男19例,女17例,平均年龄54岁。干预组又行正交设计(分4个小组、8种药因素、2个剂量水平);每小组16例患者,分别口服绿茶胶囊Ⅰ～Ⅳ,每次3粒,日3次,共24天。每月重复1疗程,维持2年。对照组用安慰剂。细胞学评价分5级:(1)好转,药后细胞学结果较药前下降1级。(2)稳定,用药前后结果基本
We tried green tea capsules I, II, III, IV intervention in patients with severe hyperplasia of the esophageal epithelium (abbreviated as re-increasing) patients, initially reversed re-increase and block the role of cancer. In October 1986, 100 patients with confirmed esophageal exfoliated cytology were randomly assigned to double-blind design. The intervention group consisted of 64 patients, 33 males and 31 females; the average age was 54 years. There were 36 patients in the placebo group, 19 males and 17 females, with an average age of 54 years. The intervention group was again subjected to orthogonal design (4 groups, 8 drug factors, 2 dose levels); 16 patients in each group were given oral green tea capsules I-IV, 3 tablets each time, 3 times daily for 24 days . Repeat 1 course every month for 2 years. Placebo was used in the control group. Cytological evaluation was divided into 5 grades: (1) improved, and the cytological result after drug was decreased by 1 level compared with that before the drug. (2) Stability, basic results before and after medication