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β-内啡肽(β-Ep)是分布于垂体、脑、肠及胰腺的一种内源性吗啡肽。缩胆囊素(CCK)是一种存在于脑及肠道的神经肽。有CCK-39肽,CCK-33肽,CCK-8肽及CCK-4肽等几种形式。下丘脑CCK-8肽的浓度提高,说明它是一种神经激素或神经递质。Vijayan曾报道,CCK-8肽有刺激大鼠生长素及催乳素分泌的效应。但CCK-8肽对垂体前叶β-Ep的分泌有何影响尚不清楚。Matsumura研究了整体及离体情况下,CCK-8肽对大鼠β-内啡肽样免疫活性物质(β-EpLI)释放的影响以及Ca~(++)与这一影响的关系。作者给成年雄性大鼠静脉注射CCK-8肽,然后断头取血,用放射免疫法测定血浆β-EpLI含量。再分
β-endorphin (β-Ep) is an endogenous morphine peptide distributed in the pituitary, brain, intestine and pancreas. Cholecystokinin (CCK) is a neuropeptide found in the brain and intestine. CCK-39 peptide, CCK-33 peptide, CCK-8 peptide and CCK-4 peptide and other forms. Hypothalamic CCK-8 peptide concentration increased, indicating that it is a neurohormonal or neurotransmitter. Vijayan reported that CCK-8 peptide has the effect of stimulating ghrelin and prolactin secretion in rats. However, the effect of CCK-8 peptide on the secretion of β-Ep in the anterior pituitary is unclear. Matsumura investigated the effect of CCK-8 peptide on the release of β-endorphin-like immunoreactive substance (β-EpLI) and the relationship between Ca ~ (++) and this effect both in whole and in vitro. The authors intravenous injection of CCK-8 peptide into adult male rats, then decapitation of blood, radioimmunoassay determination of plasma β-EpLI content. Subdivide