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在81例嗜铬细胞瘤病理分析的基础上,作了10例良性嗜铬细胞瘤(benign pheochromocytoma,BP)和2例恶性嗜铬细胞瘤(malignant pheochromocytoma,MP)的超微结构观察,其中3例做了扫描电镜。发现BP和MP瘤细胞胞浆内的分泌颗粒,明显多于对照组;深电子密度的颗粒尤多。肾上腺髓质内BP和主动脉旁BP,结构基本相同。后者瘤细胞核呈不规则型为多;核内见中等密度、园形、均质的脂滴样小体。2例青少年的MP椎体转移灶。均为肾上腺外瘤(膀胱和主动脉旁),瘤细胞呈明显异型性,BP和MP与血管关系密切,瘤细胞绕于毛细血管,小血管周围,分泌激素可见有内皮细胞逆向吞饮;血窦和小血管为弥散和管道而入血。
Based on the pathological analysis of 81 cases of pheochromocytoma, 10 cases of benign pheochromocytoma (BP) and 2 cases of malignant pheochromocytoma (MP) were observed, of which 3 were observed. Example of a scanning electron microscope. Secretory granules in the cytoplasm of BP and MP tumor cells were found to be significantly more than in the control group; particles with deep electron density were particularly abundant. Adrenal medulla BP and para-aortic BP have the same structure. The latter tumor cell nucleus was more irregular type; the nuclear see medium-density, round, homogeneous lipid droplet-like bodies. Two cases of adolescent MP vertebral metastases. All of them are extra-adrenal tumors (bladder and aorta). The tumor cells show obvious atypia. BP and MP are closely related to the blood vessels. The tumor cells surround the capillaries and around the small blood vessels. The secretion of hormones can be seen in the endothelial cells. The sinuses and small blood vessels enter the blood for dispersion and ducts.