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目的了解北京市西城区婚检人群乙型肝炎病毒(HBV)携带情况,探讨有效的预防措施,阻断HBV二代传播。方法对北京市西城区疾病预防控制中心妇幼保健所2009-2011年所有婚检对象的血清标本进行乙型肝炎病毒表面抗原(HBsAg)及丙氨酸氨基转移酶(ALT)检测资料进行分析。结果 6 125例婚检对象中,检出HBsAg阳性100例,ALT异常244例,HBsAg、ALT、HBsAg与ALT的异常检出率分别为1.63%、3.98%和0.21%。在100例HBsAg阳性者中,ALT异常率为13.00%;HBsAg阴性者中,ALT异常率为3.83%。HBsAg阳性者ALT异常率高于HBsAg阴性者。结论婚前检测HBV携带情况,早期发现HBV感染情况,在医生指导下结婚生育,对阻断HBV在配偶及下一代间的传播具有重要意义。
Objective To understand the situation of hepatitis B virus (HBV) carrier among the pre-marital population in Xicheng District of Beijing and explore effective preventive measures to block the transmission of HBV second generation. Methods Serum samples of all premarital subjects from 2009 to 2011 in Xicheng District Center for Disease Control and Prevention of MCH in Beijing were analyzed for HBsAg and ALT. Results Among the 6 125 cases of premarital examination, 100 cases of positive HBsAg and 244 cases of abnormal ALT were detected. The abnormal detection rates of HBsAg, ALT, HBsAg and ALT were 1.63%, 3.98% and 0.21% respectively. The ALT abnormality rate was 13.00% in 100 cases of HBsAg positive patients and 3.83% in HBsAg negative patients. HBsAg-positive ALT abnormalities were higher than HBsAg-negative. Conclusion Prenuptial detection of HBV carriers, early detection of HBV infection, under the guidance of doctors, marriage and childbirth, to block the spread of HBV in the spouse and the next generation of great significance.