超抗原诱导Ｔ细胞克隆缺失受到环境中多方面因素的影响。超抗原诱导Ｔ细胞Ｆａｓ系统（Ｆａｓ／ＦａｓＬ）表达升高，可导致Ｔ细胞经过Ｆａｓ／ＦａｓＬ途径而诱导凋亡，这是超抗原诱导Ｔ细胞克隆缺失的重要原因。细胞因子、抗原递呈细胞、年龄等均与超抗原诱导的Ｔ细胞克隆缺失有关，其中ＩＬ－２对Ｔ细胞克隆缺失起保护作用 Superantigen-induced deletion of T cell clones is influenced by many factors in the environment. Superantigen-induced increase of Fas / FasL expression in T cells leads to T-cell apoptosis induced by Fas / FasL pathway, which is an important reason for superantigen-induced T cell clonal deletion. Cytokines, antigen presenting cells, age and so on are associated with superantigen-induced deletion of T cell clones, in which IL-2 plays a protective role in the deletion of T cell clones