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应用CTP、IDP、ATL、NIT等四种降压药物对325例轻、中度高血压病进行了单药长疗程(1～2年)治疗研究,并设对照组50例与之比较,结果表明:四种药物的降压效果均极显著优于对照组,以IDP的显效率最高。四种药物对血脂、血糖、尿酸、肌酐等均无不良影响,对心脑并发症可能有预防效果。治疗前血压愈高,其降压效果愈佳。体重指数仅在ATL组示低指数者疗效明显优于高指数者,相关分析亦显示密切负相关。副作用均较轻微。通过综合分析,认为四种药物均可作为第一线降压药,并以IDP最优,可为首选,其次为NIT、ATL和CTP。
A total of 325 mild and moderate hypertensive patients were treated with CTP, IDP, ATL, NIT and other four antihypertensive drugs for a single long course of treatment (1-2 years), and 50 cases in the control group were compared The results showed that the antihypertensive effects of the four drugs were significantly better than the control group, IDP markedly the most efficient. Four drugs on blood lipids, blood sugar, uric acid, creatinine, etc. no adverse effects on cardiovascular and cerebrovascular complications may have preventive effects. The higher the blood pressure before treatment, the better its antihypertensive effect. The body mass index was significantly better than the high index in the ATL group showed a low index, the correlation analysis also showed a close negative correlation. Side effects are minor. Through comprehensive analysis, all four drugs are considered as first-line antihypertensive drugs, and are the best choice for IDP, followed by NIT, ATL and CTP.