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作者应用无环鸟苷治疗带状疱疹,并随机以安慰剂对照双盲试验法对其效果进行了研究.所选对象均为18岁以上成人,皮损出现72小时以内的患者.无环鸟苷静注500mg/m~2,每日3次,共5天,或注射5%葡萄糖溶液作为安慰剂.在治疗期间及治疗后2～5天,每天进行临床观察及病毒分离.治疗前后作血、尿常规及肝、肾功能等检查.治疗开始时及治疗后1周和1月分别作对水痘带状疱疹病毒膜抗原的间接免疫荧光抗体滴度的测定.
The authors applied acyclovir to treat herpes zoster and conducted a randomized placebo-controlled double-blind trial of their efficacy in adults over 18 years of age with lesions within 72 hours. Glycosides intravenously 500mg / m ~ 2, 3 times a day for 5 days, or 5% glucose solution as a placebo during the treatment and 2 to 5 days after treatment, clinical observation and daily virus isolation. Blood, urine and liver and kidney function tests, etc. At the beginning of treatment and 1 week and 1 month after treatment, respectively, for the determination of varicella zoster virus membrane antigen indirect immunofluorescence antibody titers.