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目的:探讨激素替代周期子宫内膜微创术治疗卵巢早衰患者的临床疗效及安全性。方法:选择2013年12月~2015年12月于我院进行治疗的卵巢早衰患者68例,随机分为实验组与对照组,每组34例,实验组患者采用激素替代周期子宫内膜微创术进行治疗,对照组患者服用中药抗衰复巢汤。比较治疗前后两组患者血清卵泡刺激素(FSH)、促黄体生成素(LH)及雌二醇(E2)水平,同时对两组患者的不良反应情况进行统计,治疗结束后比较两组患者的临床疗效。结果:与治疗前相比,两组患者血清FSH、LH水平均降低,E2水平均升高;治疗结束后,与对照组相比,实验组患者血清FSH、LH水平较低,E2水平较高(P<0.05),不良反应发生率较低(P<0.05),临床总有效率较高(P<0.05)。结论:应用激素替代周期子宫内膜微创术可以减少卵巢早衰患者在治疗后的不良反应,提高临床疗效。
Objective: To investigate the clinical efficacy and safety of hormone replacement period endometrial minimally invasive surgery in patients with premature ovarian failure. Methods: Sixty-eight patients with premature ovarian failure who were treated in our hospital from December 2013 to December 2015 were randomly divided into experimental group and control group with 34 cases in each group. The patients in experimental group were treated with hormone replacement of minimally invasive endometrial Surgery for treatment, the control group of patients taking traditional Chinese medicine anti-decoction complex nest soup. The levels of serum FSH, LH and E2 were compared between the two groups before and after treatment. The adverse reactions of the two groups were also statistically analyzed. After the treatment, the levels of serum FSH, Clinical efficacy. Results: Compared with the control group, serum FSH and LH levels and serum E2 levels of both groups were significantly lower than those before treatment. After treatment, the levels of serum FSH and LH were lower and the level of E2 was higher (P <0.05). The incidence of adverse reactions was lower (P <0.05) and the total effective rate was higher (P <0.05). Conclusion: Hormone replacement of endometrial minimally invasive surgery can reduce adverse reactions in patients with premature ovarian failure after treatment, improve clinical efficacy.