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目的探讨缬沙坦胶囊的降压疗效及对血浆NO、血浆细胞间粘附因子-1的影响。方法对60例高血压患者应用缬沙坦胶囊160mg,每天晨起后口服,记录每日血压和24h动态血压变化,分别于4周后、8周后取静脉血测定治疗前后血浆一氧化氮(NO)及血浆细胞间粘附因子-1(SICAM-1)水平及药物不良反应。结果缬沙坦胶囊的降压疗效显著,升高血浆NO水平,降低SICAM-1水平,并且8周后比4周后疗效更明显。结论缬沙坦胶囊是一种安全有效的降压药物,同时可以改善高血压患者血管内皮功能,降低血浆粘稠度,时间越长,获益越多,且无明显不良反应。
Objective To investigate the antihypertensive efficacy of valsartan capsule and its effect on plasma NO and plasma intercellular adhesion molecule-1. Methods Sixty patients with hypertension were treated with valsartan 160 mg orally daily after morning. The daily blood pressure and ambulatory blood pressure were recorded. Four weeks later and eight weeks later, venous blood was taken to measure the plasma levels of nitric oxide NO) and plasma intercellular adhesion molecule-1 (SICAM-1) levels and adverse drug reactions. Results Valsartan capsules showed significant antihypertensive effects, increased plasma NO levels and decreased SICAM-1 levels, and were more effective than 4 weeks after 8 weeks. Conclusion Valsartan capsules is a safe and effective antihypertensive drugs, at the same time can improve vascular endothelial function in patients with hypertension, reduce plasma viscosity, the longer, the more benefit, and no significant adverse reactions.