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矽肺是由于在生产过程中长期吸入含有游离二氧化硅粉尘而引起以肺组织纤维化为主的全身性疾病,是尘肺中危害最严重的职业病之一。其病理演化过程为与炎性有关的纤维化反应。近几年一些学者在研究矽肺的致病机制过程中发现CC16、SP-D的抗炎及抗纤维化等作用在矽肺发生发展过程中起到重要作用,并可能成为矽肺早期诊断的生物标志物。本文就它们在矽肺诊断中的价值作一简单介绍。
Silicosis is one of the most serious occupational diseases in pneumoconiosis due to systemic diseases caused by long-term inhalation of free silica dust inhaled during the production process. The pathological evolution of inflammation-related fibrosis. In recent years, some scholars found that the anti-inflammatory and anti-fibrosis effects of CC16 and SP-D in the pathogenesis of silicosis have played an important role in the development of silicosis and may become the biomarker for the early diagnosis of silicosis . This article gives a brief introduction of their value in the diagnosis of silicosis.