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目的：研究静脉注射索他洛尔（ｓｏｔａｌｏｌ）对非器质性心脏病患者的心脏电生理作用及安全性。 方法：受试者１０例，１５分钟内静脉注射盐酸索他洛尔０．８ ｍ ｇ／ｋｇ，继以０．６ ｍ ｇ／（ｋｇ·ｈ）匀速静脉泵入。于用药前和静脉泵入１５ 分钟时分别行心脏电生理检查并记录右心室单向动作电位。 结果：用药后窦性周长、窦房结恢复时间和校正的窦房结恢复时间延长（Ｐ＜ ０．０５），窦房传导时间不变。ＡＨ间期及房室结顺传文氏周期延长（Ｐ＜ ０．０１）。心电图ＰＲ、ＱＴ、校正ＱＴ及ＪＴ间期均延长（Ｐ＜ ０．０５），ＱＲＳ间期不变。心房、房室结及心室相对不应期、功能不应期及有效不应期（ＥＲＰ）延长。右心室单向动作电位时间（ＭＡＰＤ９０ ）延长（Ｐ＜ ０．０１），而ＥＲＰ／ＭＡＰＤ９０不变。未发现明显不良反应。 结论：静脉索他洛尔兼有Ⅱ类及Ⅲ类抗心律失常作用，国人对０．８ ｍ ｇ／ｋｇ 耐受性良好。
Objective: To investigate the cardiac electrophysiological effects and safety of intravenous sotalol in patients with non-structural heart disease. Methods: Ten patients were injected intravenously with sotalol hydrochloride 0.8 m g / kg in 15 minutes, followed by 0.6 m g / (kg · h) intravenous infusion. Before medication and intravenous infusion of 15 minutes, respectively, cardiac electrophysiological examination and record right ventricular unilateral action potential. Results: The sinus circumference, sinus node recovery time and corrected sinus node recovery time were prolonged (P <0.05), and the time of sinus node conduction was unchanged. AH interval and atrioventricular node Wen Du cycle extension (P <0.01). ECG PR, QT, corrected QT and JT interval were prolonged (P <0.05), QRS interval unchanged. Atrial, atrioventricular node and ventricular refractory period, refractory period and effective refractory period (ERP) to extend. Right ventricular unilateral action potential time (MAPD90) was prolonged (P <0.01), while ERP / MAPD90 unchanged. No obvious adverse reactions were found. Conclusions: Both intravenous sotalol and anti-arrhythmic effects of class II and class III are tolerable, and the Chinese are well tolerated at 0.8 m g / kg.