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[目的]制备酮康唑固体脂质纳米粒(SLN),并对其进行质量评价.[方法]采用微乳法制备酮康唑SLN,以包封率为评价指标,通过正交设计试验筛选最佳处方,并对其包封率、粒径等进行考察.[结果]按照最佳处方制备的酮康唑SLN在透射电子显微镜下呈圆整球形,大小分布均匀,平均粒径为61.7nm,Zeta电位为-23.84mV,平均包封率为75.75%.[结论]用本处方制备酮康唑SLN稳定,可行.
[Objective] The research aimed to prepare the solid lipid nanoparticles (SLN) of ketoconazole and evaluate the quality of it.Methods The ketoconazole SLN was prepared by microemulsion method, the encapsulation efficiency was used as the evaluation index, The best prescription, and its entrapment efficiency, particle size, etc. were investigated. [Results] The ketoconazole SLN prepared according to the best prescription was round and spherical under the transmission electron microscope, the size distribution was uniform, the average particle size was 61.7nm , The zeta potential was -23.84mV and the average encapsulation efficiency was 75.75%. [Conclusion] The preparation of ketoconazole SLN by this prescription is stable and feasible.