利血平巳在国內外广泛应用于治疗高血压病及精神病。但对它的中枢作用机制未完全了解。Bein指出,利血平的作用主要是抑制下視丘交感神經中枢的活动。Schncider观察到大剂量的利血平能兴奋脊髓突触的传导,并推測由于增进大脑皮层的突触传导,加強了对下视丘的抑制,因而减低了中枢性交感张力。其他学者如Weiskrantz,Smith,Miffii,John等分別指出利血平对猴、大白鼠及猫的条件性防御反 Reserpine has been widely used in the treatment of hypertension and psychosis at home and abroad. But its central mechanism of action is not fully understood. Bein pointed out that the main role of reserpine is to inhibit the activity of the hypothalamus sympathetic center. Schncider observed that high doses of reserpine stimulated spinal cord synaptic transmission and hypothesized that central sympathetic tone was reduced by increasing synaptic transmission in the cerebral cortex and increasing suppression of the hypothalamus. Other scholars such as Weiskrantz, Smith, Miffii, John and others point out the conditional defensiveness of reserpine to monkeys, rats and cats respectively