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8440(吡喹酮)是一种新的广谱抗血吸虫药物。国内已经合成,在治疗血吸虫病方面已取得较好的效果。我们在南京药物研究所的支持下,对华枝睾吸虫病进行了动物实验治疗,并对11例儿童华枝睾吸虫病进行了临床治疗观察,兹将初步结果报告如下: 一、动物实验治疗 自华枝睾吸虫病流行区购得新鲜麦穗鱼,查获囊幼后,将鱼肉捣碎,喂健康豚鼠,每只喂囊幼约100个,感染后半月开始粪检,发现虫卵后作为治疗对象。约感染一个月后用8440进行实验治疗。共感染豚鼠6只,每组2只,第一组用8440,每公斤体重100毫克,每日一次,连服三天,第二组用每公斤50毫克,每日一次,连服三天。
8440 (praziquantel) is a new broad-spectrum anti-schistosome drug. China has been synthesized, in the treatment of schistosomiasis has achieved good results. With the support of Nanjing Institute of Materia Medica, we conducted experimental animal experiments on the treatment of Clonorchis sinensis, and observed the clinical treatment of 11 cases of Clonorchis sinensis in children. The preliminary results are reported as follows: 1. Experimental Animal Treatment Fresh crested fish were purchased from the endemic area of Clonorchis sinensis, and after the young were seized, the fish were mashed, then healthy guinea pigs were fed. Each young feeding cane was about 100 young. After the infection half a month, Treatment object. One month after infection with 8440 for experimental treatment. A total of 6 guinea pigs were infected with 2 rats in each group. The first group used 8440, 100 mg per kg of body weight once daily for three days. The second group received 50 mg / kg once daily for even three days.