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69例糖尿病周围神经病变的患者随机分为两组,治疗组给予α硫辛酸联合前列腺素E1,对照组给予单用前列腺素E1治疗。其他治疗手段相同,疗程共3周。比较两组治疗前后症状和神经传导速度。两组治疗后密歇根糖尿病神经病变评分量表(MDNS)及密歇根糖尿病神经病变筛查量表(MNSI)评分和神经传导速度均较治疗前改善(P均<0.05),联合用药组改善幅度明显高于单药组(P<0.05)。α硫辛酸联合前列腺素E1治疗糖尿病周围神经病变疗效较好。
69 patients with diabetic peripheral neuropathy were randomly divided into two groups, the treatment group given alpha lipoic acid combined with prostaglandin E1, the control group given single prostaglandin E1 treatment. Other treatment the same, a total of 3 weeks. The symptoms and nerve conduction velocity before and after treatment were compared between the two groups. After treatment, the scores of the Michigan Diabetic Neuropathic Disease Scale (MDNS) and the Michigan Diabetic Neuropathic Screening Scale (MNSI) and the nerve conduction velocity were improved compared with those before treatment (all P <0.05), and the improvement rate in the combination group was significantly higher In single drug group (P <0.05). Alpha lipoic acid combined with prostaglandin E1 for the treatment of diabetic peripheral neuropathy better.