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Objective To investigate the effects of Jiaosanxian(JSX,consisted of stir-baked Hordei Fructus GerminatusCrataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid. Methods The model of hyperlipidemic mice was established by feeding high-fat diet. Kunming mice were randomly divided into six groups: blank,hyperlipidemic,Zhibituo,low-,mid-,and high-dose [100,200,and 400 mg/(kg·d)] JSX groups,and were continuously ig administered for 28 d. The contents of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C) in serum and liver and liver index were determined. Results The contents of TC,TG,and LDL-C in serum or liver were decreased significantly but the contents of HDL-C were increased more significantly in the mid- and high-dose JSX groups than those in hyperlipemic group. The weight and liver index were decreased significantly with the dose increasing of JSX. The lipid-decreasing effects were improved with the dose increasing. Conclusion These results suggest that JSX has the significant effects on hyperlipidemia. It could provide the experimental basis for the clinical use of JSX for the treatment of hyperlipidemia.
Objective To investigate the effects of Jiaosanxian (JSX, consisted of stir-baked Hordei Fructus GerminatusCrataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid. Methods The model of hyperlipidemic mice was established by feeding high-fat diet. Kunming mice were randomly divided into six groups: blank, hyperlipidemic, Zhibituo, low-, mid-, and high-dose [100,200, and 400 mg / (kg · d)] JSX groups, and were continuously administered for 28 days. TC, TG, LDL-C), high density lipoprotein cholesterol (HDL-C) in serum and liver and liver index were determined. Results The contents of TC, TG, and LDL- C in serum or liver were decreased significantly but the contents of HDL-C were increased more significantly in the mid- and high-dose JSX groups than those in hyperlipemic group. The weight and liver index were decreased significantly with the dose increasing of JSX. The lipid-decreasing effects were improve Conclusion These results suggest that JSX has the significant effects on hyperlipidemia. It could provide the experimental basis for the clinical use of JSX for the treatment of hyperlipidemia.