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目的探讨HPV检查在宫颈炎、宫颈癌前期病变、宫颈癌中的含量及临床意义。方法对符合诊断标准的145例宫颈炎、宫颈癌前病变、宫颈癌患者进行HPV检测及其中HPV阳性者进一步检测HPY-DNA亚型的构成情况。并对检查结果进行分析。结果宫颈炎、宫颈癌前期病变、宫颈癌之间HPV阳性例数及含数值差异有统计学意义(P<0.05),其中宫颈癌HPV阳性例数及含量值明显升高。HPV阳性患者中HPV-DNA-16阳性率83.1%、HPVDNA-18阳性率68.9%。结果高危HPVDNA类型检测有助于宫颈癌的早期诊断,具有积极的临床价值。结论HPV检测及HPV阳性者检测DNA亚型分类在临床上可帮助宫颈癌早发现,早诊断及治疗。
Objective To investigate the content and clinical significance of HPV test in cervicitis, cervical precancerous lesions and cervical cancer. Methods 145 cases of cervicitis, precancerous lesions of cervical cancer and cervical cancer patients who were diagnosed according to the diagnostic criteria were tested for the HPV genotypes and HPY-DNA subtypes by HPV test. And analyze the test results. Results Cervical inflammation, precancerous lesions of cervical cancer, cervical cancer between the number of HPV positive cases and the value of the difference was statistically significant (P <0.05), including cervical cancer HPV positive cases and levels were significantly higher. The positive rate of HPV-DNA-16 in HPV-positive patients was 83.1% and the positive rate of HPV DNA-18 was 68.9%. Results High-risk HPV DNA detection could be helpful for the early diagnosis of cervical cancer. It has positive clinical value. Conclusion The HPV subtypes detected by HPV test and HPV positive test can help early detection, early diagnosis and treatment of cervical cancer in clinic.