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多种研究表明上皮细胞间质转化(EMT)与上皮细胞恶性肿瘤的发生和发展关系密切。EMT是上皮细胞获得迁移能力的有效方式,在成体中成为占恶性肿瘤90%以上的上皮细胞癌浸润转移的一个重要途径。目前体内和体外实验证据都表明,EMT在乳腺癌、结肠癌、肺癌、前列腺癌、肝癌、胰腺癌等多种癌症的原发性浸润和继发性转移中起着举足轻重的作用。本研究从EMT的分类、生物标记物以及与恶性肿瘤浸润和转移的关系等方面进行综述。
A variety of studies have shown that epithelial cell stromal transformation (EMT) is closely related to the occurrence and development of epithelial malignant tumors. EMT is an effective way for epithelial cells to acquire the ability to migrate and become an important pathway in the invasion and metastasis of epithelial cell carcinoma which accounts for more than 90% of malignant tumors in adult body. At present, in vitro and in vivo experimental evidence shows that EMT plays a pivotal role in the primary invasion and secondary metastasis of many cancers such as breast cancer, colon cancer, lung cancer, prostate cancer, liver cancer and pancreatic cancer. This review summarizes the classification of EMT, biomarkers and the relationship with the invasion and metastasis of malignant tumors.