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Graves’病(GD)是自身免疫性疾病,以甲状腺腺体淋巴细胞浸润和TSH受体刺激抗体的产生为特征。抗甲状腺药物、手术和放射性碘是三种常用的疗法,但没有一种为理想手段,药物治疗具有易控制的优点,最终缓解仍可保持甲状腺完整,无甲减的危险性。虽药物可导致最终缓解,但复发危险性较大,复发率多数资料报道为50%～70%。作者为了弄清与长期抗甲状腺药物治疗复发有关的治疗前的各种因素,进行了以下的试验。
Graves’ disease (GD) is an autoimmune disease characterized by thyroid gland lymphocyte infiltration and TSH receptor stimulated antibody production. Antithyroid drugs, surgery and radioactive iodine are three commonly used therapies, but none of them are ideal and medical treatments have the advantage of being easy to control. Ultimately, remission can still keep thyroid intact and without hypothyroidism. Although the drug can lead to the ultimate remission, but the greater the risk of relapse, most of the recurrence rate reported as 50% to 70%. The authors conducted the following tests to understand the various pre-treatment factors associated with the long-term anti-thyroid drug treatment relapse.