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目的 研究静脉吸毒人群甘露糖结合凝集素MBL2变异对丙型肝炎病毒(HCV)感染的影响. 方法 选取 2016年湖南省白泥湖强制隔离戒毒所HCV阳性静脉注射吸毒者453例,健康对照453例,抽取外周静脉血,进行HCV检测及MBL-2基因型检测,分析MBL2的15种单核苷酸多态性基因型及其HCV感染的相关性,比较吸毒人群和健康人群的基因型差异. 结果 453例HCV 阳性静脉注射吸毒者中109例HCV 抗体阳性,HCV RNA 阴性;344例 HCV抗体和RNA皆阳性.导致MBL缺乏的遗传变异和HCV RNA的存在两者之间无显著相关性.与健康人群相比导致MBL缺乏的MBL2-289X启动子基因型在HCV RNA阴性吸毒人群中呈过度表达(OR=1.65,95％ CI 1.05- 2.58). 结论 导致MBL缺乏遗传变异和HCV RNA的存在无关联.吸毒者中MBL2-289X与HCV RNA有关联,但尚需进一步验证.“,”Objective To investigate whether MBL2variations in intravenous drug users and normal individuals affects hepatitis C virus(HCV)infection. Methods Subjects included 453drug users in the Bainihu Compulsory Isolated Detoxification Center in Hunan Province in 2016and 453healthy people serving as controls.Peripheral venous blood was sampled,HCV was detected,and the MBL-2 gene was detected.The correlation between 15SNP genotypes of MBL-2 and HCV infection was analyzed,and differences in genotypes were compared in drug users and healthy controls. Results Among the drug users,109tested positive for antibodies against HCV and negative for HCV RNA.Three hundred and forty-four drug users tested positive for both antibodies against HCV and HCV RNA.There was no significant correlation between genetic variations leading to an MBL deficiency and the presence of HCV RNA.The MBL2-289Xpromoter genotype that causes an MBL deficiency was overexpressed in drug users who tested negative for HCV RNA compared to healthy controls(OR=1.65,95％ CI 1.05-2.58). Conclusion This study found no association between genetic variations that lead to an MBL deficiency and the presence of HCV RNA.MBL2-289Xwas associated with the presence of HCV RNA in the drug users studied.