先证者李×,男,28岁,因婚后1年多其妻无明显诱因流产2次而就诊。体检:身体发育良好,智利正常。其妻表型正常。先证者之母共妊娠4次,流产2次,生育2个表型正常的男孩,先证者之弟尚未结婚。 对夫妇双方及家系中有关人员进行染色体检查,结果先证者妻子和父亲染色体正常,先证者及母亲的 Proximity Lee ×, male, 28 years old, more than 1 year after marriage, his wife had no obvious incentive to abortion 2 times for treatment. Physical examination: Physical well-being, Chile normal. His wife phenotype is normal. The mother of the proband, a total of 4 pregnancies, abortion 2 times, giving birth to two boys with normal phenotype, the younger brother of proband yet to marry. Chromosome examination was conducted on both husband and wife and relatives of the family members. As a result, the proband’s wife and father had normal chromosomes, probands and mothers