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目的 :制备氯氮平 (Clozapine)缓释片剂。方法 :以羟丙基甲基纤维素 (Hydroxypropylmethylcellose ,HPMC)为骨架材料 ,制成氯氮平亲水凝胶缓释骨架片。筛选该缓释片的最佳处方并进行稳定性研究。结果 :处方 7具有很好的缓释效果 ,稳定性研究表明该缓释片的稳定性良好。结论 :处方 7为优良缓释片。
Objective: To prepare Clozapine sustained-release tablets. METHODS: Hydroxypropylmethylcellose (HPMC) was used as matrix material to prepare clozapine hydrophilic gel sustained-release matrix tablets. The optimal formulation of this sustained-release tablet was screened and studied for stability. Results: Prescription 7 has a good sustained-release effect, stability studies show that the sustained-release tablets with good stability. Conclusion: Prescription 7 is a good sustained-release tablets.