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目的：观察老年大鼠血浆环核苷酸的变化及人参，黄芪的调节作用。方法：放射免疫分析法。结果：老年大鼠ｃＡＭＰ，ｃＧＭＰ含量显著高于青年大鼠，但ｃＡＭＰ／ｃＧＭＰ比值降低（Ｐ＜００５），人参，黄芪均可以纠正这三项指标的改变，使之与青年大鼠接近。结论：对血浆环核苷酸的调节是人参和黄芪抗衰老作用的一个方面。
OBJECTIVE: To observe the changes of plasma cyclic nucleotides and the regulatory effects of ginseng and astragalus in aged rats. Methods: Radioimmunoassay. Results: The cAMP and cGMP contents of aged rats were significantly higher than those of young rats, but the cAMP/cGMP ratio was lower (P<0. 05). Both ginseng and astragalus could correct these three indicators and make them close to the young rats. . CONCLUSIONS: Regulation of plasma cyclic nucleotides is one aspect of the anti-aging effects of ginseng and astragalus.