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目的与方法：利用大鼠离体心脏Ｌａｎｇｅｎｄｏｒｆ灌注模型，研究氟烷和异氟醚对缺血再灌注心肌收缩功能和ＡＴＰ含量的影响。结果与结论：１．５ＭＡＣ的氟烷显著抑制了大鼠离体心肌收缩力，而１．５ＭＡＣ的异氟醚对大鼠离体心肌收缩力无显著影响。两药均显著增加了ＣＦ，但异氟醚增加ＣＦ的作用大于氟烷。缺血期间，氟烷和异氟醚显著抑制了心肌缺血性挛缩。再灌注期间，两药均显著促进了缺血心肌收缩功能，ＣＦ和ＡＴＰ含量恢复，但是异氟醚促进心肌收缩功能恢复的作用显著大于氟烷。异氟醚组ＣＦ恢复较好，ＡＴＰ再合成能力较强，可能是异氟醚对缺血心肌具有较好保护作用的重要原因。
PURPOSE AND METHODS: The effects of halothane and isoflurane on myocardial contractile function and ATP content in ischemia-reperfusion myocardium were studied by using Langendorf perfusion model in vitro. RESULTS AND CONCLUSION: Hyaluronan at 1.5MAC significantly inhibited the contractile force of isolated rat myocardium, whereas isoflurane at 1.5MAC had no significant effect on isolated rat contractile force. Both drugs significantly increased CF, but the effect of isoflurane to increase CF was greater than that of halothane. Hyaluronan and isoflurane significantly inhibited myocardial ischemic contractures during ischemia. During reperfusion, the two drugs significantly promoted the contractile function of ischemic myocardium and restored the contents of CF and ATP, but the effect of isoflurane on the recovery of myocardial contractile function was significantly greater than that of halothane. Isoflurane group CF recovery is better, ATP re-synthesis ability, may be isoflurane on ischemic myocardium has a good protective effect of the important reasons.