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腺苷和一氧化氮(Nitric oxide,NO)都是十分活跃的具有多种生物活性的内源性物质。近年来,关于腺苷和NO在周围组织和中枢神经系统中的相互作用被广泛关注。腺苷在中枢神经系统中广泛存在,可作为整合中枢兴奋和抑制性神经递质的调节因子;NO在中枢神经系统中具有广泛的生物学意义,既兼有第二信使和神经递质的性能,又是效应分子,参与多种生理功能,代谢衍生物有一定的中枢神经毒性。在中枢神经系统中,腺苷和NO之间可能有一定联系,本文综述了二者在中枢神经系统中的相互作用及其与癫痫的相关性,以期为中枢神经系统相关疾病的发病机制研究及防治方法提供新的思路。
Both adenosine and nitric oxide (NO) are very active endogenous substances with a variety of biological activities. In recent years, attention has been focused on the interaction between adenosine and NO in the surrounding tissues and the central nervous system. Adenosine is widespread in the central nervous system and serves as a regulator of the central nervous system’s excitatory and inhibitory neurotransmitters; NO has a wide range of biological significance in the central nervous system, combining both the second messenger and neurotransmitter properties , Is also an effector, involved in a variety of physiological functions, metabolic derivatives have some central neurotoxicity. In the central nervous system, adenosine and NO may have some connections, this article reviews the two in the central nervous system interaction and its relationship with epilepsy in order to study the pathogenesis of central nervous system-related diseases and Prevention methods provide new ideas.