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目的:探讨c-Jun、c-Fos在皮肤恶性黑素瘤中的表达及意义。方法:采用免疫组化法检测45例皮肤恶性黑素瘤、34例瘤旁组织和20例色素痣中c-Jun、c-Fos的表达。结果:(1)c-Jun、c-Fos在皮肤恶性黑素瘤、瘤旁组织中的阳性表达率明显高于色素痣;(2)c-Jun、c-Fos在皮肤恶性黑素瘤中的表达与浸润深度有关,与淋巴结转移无关;(3)皮肤恶性黑素瘤中c-Jun、c-Fos的表达呈显著正相关。结论:c-Jun、c-Fos可作为皮肤恶性黑素瘤早期诊断的生物学标记。
Objective: To investigate the expression and significance of c-Jun, c-Fos in cutaneous malignant melanoma. Methods: Immunohistochemistry was used to detect the expression of c-Jun and c-Fos in 45 cases of cutaneous malignant melanoma, 34 cases of para-tumor tissues and 20 cases of pigmented nevus. Results: (1) The positive expression rate of c-Jun, c-Fos in skin malignant melanoma and paraneoplastic tissues was significantly higher than that of pigmented nevus; (2) c-Jun, c-Fos in cutaneous malignant melanoma The expression of c-Jun and c-Fos in skin malignant melanoma was significantly correlated with the depth of invasion and lymph node metastasis. Conclusion: c-Jun and c-Fos can be used as biomarkers for the early diagnosis of cutaneous malignant melanoma.