托吡酯(topiramate,TPM)商品名妥泰,1996年首次应用于临床,目前作为一种新的抗癫药被广泛应用,具有多种抗癫的机制和广泛的药理学特性。除抗癫外还有神经保护、治疗偏头痛、减轻体质量等作用,国内外学者对其神经保护作用和疼痛治疗方面做了大量的临床和试验研究,也对其神经保护和治疗疼痛机制进行了研究。本文重点阐述其神经保护作用,就其研究现状做一综述。 Topiramate (topiramate, TPM) trade name Topotec, first applied to clinical in 1996, is currently widely used as a new anti-epileptic drug, with a variety of anti-epileptic mechanisms and a wide range of pharmacological properties. In addition to antiepileptic neuroprotection, treatment of migraine, reduce body weight and other effects of domestic and foreign scholars on its neuroprotective effects and pain treatment done a lot of clinical and experimental studies, but also its neuroprotection and treatment of pain mechanism Study. This article focuses on its neuroprotective effects, to review its current status.