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目的：研究ＡｇＮＯＲ和ＮＤＰＫ／ｎｍ２３与乳腺癌预后的关系。方法：对５２例乳腺癌作ＡｇＮＯＲ计数及ＮＤＰＫ／ｎｍ２３免疫组化染色。结果：ＡｇＮＯＲ＜４者，５年生存率显著高于ＡｇＮＯＲ≥４者。ＮＤＰＫ／ｎｍ２３阳性者，５年生存率显著高于ＮＤＰＫ／ｎｍ２３阴性者。ＡｇＮＯＲ＜４、ＮＤＰＫ／ｎｍ２３阳性者，５年生存率高于ＡｇＮＯＲ≥４、ＮＤＰＫ／ｎｍ２３阴性者。ＡｇＮＯＲ≥４者在ＮＤＰＫ／ｎｍ２３阴性组较ＮＤＰＫ／ｎｍ２３阳性组显著增多，表明两者之间存在一定的关系。结论：ＡｇＮＯＲ与预后呈负相关，ＮＤＰＫ／ｎｍ２３与预后呈正相关。
Objective: To investigate the relationship between AgNOR, NDPK/nm23 and the prognosis of breast cancer. Methods: AgNOR counts and NDPK/nm23 immunohistochemical staining were performed in 52 cases of breast cancer. Results: The 5-year survival rate of AgNOR<4 was significantly higher than those with AgNOR≥4. In patients with positive NDPK/nm23, the 5-year survival rate was significantly higher than those with negative NDPK/nm23. The 5-year survival rate of AgNOR<4, NDPK/nm23-positive patients was higher than those with AgNOR ≥4 and NDPK/nm23-negative patients. AgNOR ≥ 4 was significantly increased in the NDPK/nm23 negative group compared with the NDPK/nm23 positive group, indicating a certain relationship between the two. Conclusion: AgNOR is negatively correlated with prognosis. NDPK/nm23 is positively correlated with prognosis.