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药物研究的历史表明,天然产物是新药发现的重要来源,提高天然产物的研究水平,提高从天然产物中发现先导化合物或药物的效率,需要技术的进步和研究方法的改进。本文根据应用现代天然产物分离提取技术和高通量药物筛选技术研究天然产物先导化合物的实际工作情况,探讨从天然产物中快速发现先导化合物的新策略和新方法,以推进活性化合物或药物先导化合物的发现进程,促进我国的创新药物研究。
The history of drug research shows that natural products are an important source of discovery of new drugs. Improving the research level of natural products and increasing the efficiency of discovering lead compounds or drugs from natural products requires technological advances and improvements in research methods. Based on the application of modern natural product separation and extraction technology and high-throughput drug screening technology to study the actual work of natural product lead compounds, we explored new strategies and new methods for rapid discovery of lead compounds from natural products to advance active compounds or drug lead compounds. The discovery process promotes the research of innovative drugs in China.