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目的:探讨MAOA-uVNTR多态性与儿童早期问题行为间的关系是否因年龄和性别而异。方法:在24和36个月时,采用婴幼儿社会情绪量表测量202名儿童的问题行为。通过PCR扩增技术和琼脂糖凝胶电泳检测技术分析所采集的口腔脱落细胞的基因多态性。结果:①24个月时,3型男孩比4型男孩表现更多违抗,但在同伴攻击、焦虑/抑郁和抑制/退缩上无差异;36个月时,MAOA基因对男孩违抗的影响只达到边缘显著水平。②24个月时,3/3和3/4型女孩表现更多同伴攻击,但在违抗、抑郁/焦虑和抑制/退缩上无差异;36个月时,4/4型女孩在抑制/退缩上的水平较高。结论:MAOA-uVNTR多态性对男孩违抗和女孩同伴攻击的影响随着年龄的增长而降低,但对女孩的抑制/退缩的影响随着年龄的增长而增加。
Objective: To investigate whether the relationship between MAOA-uVNTR polymorphism and early childhood behavior varies according to age and gender. METHODS: Twenty-two children’s behavioral problems were measured using the Social and Emotional Scale for Infants and Toddlers at 24 and 36 months. The gene polymorphisms of oral exfoliated cells were analyzed by PCR amplification and agarose gel electrophoresis. RESULTS: At 24 months, Type 3 boys showed more disobedience than Type 4 boys, but there was no difference in peer attacks, anxiety / depression and depression / withdrawal; at 36 months MAOA genes only had marginal effects on boys’ defiance Significant level. At 24 months, girls in 3/3 and 3/4 showed more fellow attacks but did not differ in defensiveness, depression / anxiety and inhibition / withdrawal; at 36 months, 4/4 girls were significantly more likely to suppress / decline The higher the level. CONCLUSIONS: The effects of MAOA-uVNTR polymorphism on boy defenses and girl peer attacks decrease with age, but the impact on girl suppression / withdrawal increases with age.