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目的:制备壳聚糖-β-环糊精药物载体,以期开发β-环糊精在疏水性药物缓释制剂方面的潜在应用价值。方法:采用共价键使壳聚糖与β-环糊精偶联,利用红外光谱(IR)、核磁共振氢谱(~1H-NMR)以及X-射线衍射(X-RD)对偶合物进行表征,运用元素分析法对偶合物中的β-环糊精进行定量。结果:壳聚糖与β-环糊精成功偶联,β-环糊精取代度为13%。结论:通过亲核取代反应,可以成功将β-环糊精嫁接到壳聚糖分子上。
OBJECTIVE: To prepare the drug carrier of chitosan-β-cyclodextrin in order to develop the potential application of β-cyclodextrin in the formulation of sustained-release hydrophobic drug. Methods: The chitosan was coupled with β-cyclodextrin by covalent bond. The conjugate was characterized by IR, 1H-NMR and X-ray diffraction (X-RD) Characterization, the use of elemental analysis of β-cyclodextrin in the conjugate quantitative. Results: Chitosan was successfully coupled with β-cyclodextrin. The degree of substitution of β-cyclodextrin was 13%. Conclusion: β-Cyclodextrin can be successfully grafted onto chitosan molecules by nucleophilic substitution reaction.