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为了解喉部鳞状细胞癌中表皮生长因子受体（EGF－R）的表达与临床特征、细胞分化及预后的关系，作者通过免疫组织化学方法（S－P法）检测了36例喉部鳞状细胞癌的石蜡标本，发现24例出现EGF－R阳性表达，其表达率为66．7％，作为对照组的25例喉旁正常组织中只有1例出现EGF－R阳性表达；EGF－R阳性表达与患者的年龄（≤60岁、＞60岁）、肿瘤部位无相关性（P＞0．05）；而与TNM分期、组织分化程度有明显的相关性（P＜0．05）,4例复发癌均为EGF－R高表达；在伴颈淋巴结转移的7例中，有6例EGF－R为高表达。提示EGF－R表达与喉鳞状细胞癌的癌细胞的无限制生长、分裂的机理有一定关系，EGF－R高表达可作为病人预后较差的参数之一。
In order to understand the relationship between the expression of epidermal growth factor receptor (EGF-R) and clinical features, cell differentiation and prognosis in laryngeal squamous cell carcinoma, the authors detected 36 cases of larynx by immunohistochemistry (S-P method) Squamous cell carcinoma of the paraffin specimens and found EGF-R positive expression in 24 cases, the expression rate was 66.7%, 25 cases of normal laryngeal tissue as a control group, only one case of EGF-R positive expression; EGF- R was positively correlated with the age of patients (≤ 60 years old,> 60 years old) and tumor site (P> 0.05), but not with the TNM stage and histological differentiation (P <0.05) , 4 cases of recurrence of cancer are EGF-R high expression; in 7 cases with cervical lymph node metastasis, 6 cases of EGF-R is high expression. It is suggested that the expression of EGF-R is related to the unrestricted growth and division of cancer cells in laryngeal squamous cell carcinoma. The high expression of EGF-R may be one of the parameters with poor prognosis.