子痫前期一子痫(preeclampsia-eclampsia,PE-E)是妊娠期特发性高血压疾病,可伴有脑、心、肝、肾等多脏器损害,是导致孕产妇及围产儿病率和死亡率升高的主要原因。对于此病的研究进程,始终以人们对其临床症状的认识为基础。早在18世纪,人们就认识到PE-E是一种急症,患者可出现蛋白尿。随着对此病临床症状的不断认识,对其病因和发病机理的研究也在不断深入,但到目前为止,PE-E的发病机理仍未完全清楚,是全球产科界的难解之题。 Preeclampsia-eclampsia (PE-E) is an idiopathic hypertensive disorder complicating pregnancy. It can be associated with multiple organ damage such as brain, heart, liver and kidney. It is the cause of maternal and perinatal morbidity And the main reason for the increase in mortality. The research process for this condition has always been based on an understanding of its clinical symptoms. As early as the 18th century, PE-E was recognized as an emergency and patients developed proteinuria. With the continuous understanding of the clinical symptoms of the disease, the etiology and pathogenesis of the research is also in-depth, but so far, PE-E pathogenesis is still not fully understood, is the global obstetric community difficult problem.