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目的:研究瓜蒌皮注射液干预急性心肌梗塞的作用效果,并探讨其机制。方法:结扎大鼠冠脉动脉,制备冠心病急性心肌梗死模型。丹参注射液为阳性对照药。大鼠腹腔注射给药。氯化三苯四氮唑染色(TTC),测定心肌梗死率;生化试剂盒检测血浆中肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)、羟基丁酸脱氢酶(α-HBDH)和乳酸脱氢酶(LDH)5项心肌酶活性,确定心肌细胞坏死程度;生化试剂盒检测血浆中内皮素(ET)、一氧化氮(NO)含量及内皮型一氧化氮合酶(eNOS)的活性,明确瓜蒌皮注射液调节血管舒张的能力。结果:对急性心肌缺血大鼠,瓜蒌皮注射液可显著降低其心肌梗死率及血浆中5项心肌酶活性,提高eNOS活性及NO分泌量,降低ET含量,维护缺血心肌正常生理功能,作用效果与丹参注射液无显著性差异。结论:瓜蒌皮注射液可能通过抑制ET的合成、激活eNOS活性,提高NO分泌量,增强冠状动脉的扩张,增加冠脉流量;从而实现对大鼠急性心肌梗塞的保护作用。
Objective: To study the effect of Gupepi injection on acute myocardial infarction (AMI) and explore its mechanism. Methods: The coronary arteries of rats were ligated to prepare acute myocardial infarction model of coronary heart disease. Salvia injection for the positive control drug. Rats were administered intraperitoneally. TTC was used to determine the myocardial infarction rate. The levels of creatine kinase (CK), creatine kinase (CK-MB), aspartate aminotransferase (AST) The activity of 5 enzymes of α-HBDH and LDH were determined to determine the degree of cardiomyocyte necrosis. The levels of ET, Type nitric oxide synthase (eNOS) activity, clear melon skin injection regulates vasodilation capacity. Results: Acute myocardial ischemia in rats, melon skin injection can significantly reduce the myocardial infarction rate and plasma 5 myocardial enzyme activity, increase eNOS activity and NO secretion, reduce ET content, maintain normal physiological function of ischemic myocardium , The effect and Salvia injection no significant difference. Conclusion: Gu Kui skin injection may inhibit the synthesis of ET, activate eNOS activity, increase the secretion of NO, enhance the expansion of coronary artery and increase the coronary flow; thus achieve the protection of acute myocardial infarction in rats.